Microfluidics

The LM20 contains an intensifier pump designed to supply the desired pressure at a constant rate to the product stream. As the pump travels through its pressure stroke, it drives the product at constant pressure through precisely defined fixed-geometry microchannels within the interaction chamber.

As a result, the product stream accelerates to high velocities, creating shear rates within the product stream that are orders of magnitude greater than any other conventional means. All of the product experiences identical processing conditions, producing the desired results, including: uniform particle and droplet size reduction (often submicron), deagglomeration and high-yield cell disruption.

The LV1 benchtop was developed as a result of customer demand to bring Microfluidizer quality nanotechnology processing to the milliliter scale with applications in the pharmaceutical, biotechnology, chemical, nutraceutical/food, cosmetic and energy industries:

• Academic and commercial sectors
• Drug discovery, Adme Tox, basic research and development
• Proteomics and genomics applications

Microfluidizer processors offer exclusive benefits due to the fixed-geometry interaction chamber and constant pressure pumping system. The unique technology enables customers to achieve smaller sample sizes than other methods with more uniform distribution and scaleup guaranteed.

With the LV1, researchers with limited resources and high value samples are able to enhance their wide variety of applications and materials with benefits only a Microfluidizer processor can provide:

• Stable nanoemulsions
• Highest protein recovery (typically >99% for E. coli after one pass)
• Challenging cell disruption (e.g. yeast, insect cells)
• Improved bioavailability
• Targeted delivery
• Nanoencapsulation (e.g. polymers, liposomes )
• Deagglomeration

As leading pharmaceutical companies continue to explore the benefits of continuous manufacturing and bottom-up nanoparticle creation, Microfluidics’ PureNano Continuous Crystallizer is being used to create stabile inhalable formulations, improve the bioavailability of antibiotics and target delivery of novel cancer treatments, among other possibilities.

Microfluidizer homogenizers combine superior results with easy handling and small footprint.

The series of air-driven homogenizers are lightweigh and easy-to-use and are suitable for batch and continuous flow processing, often used for emulsions, dispersions and liposomes in pharmaceutical, cosmetic and food and beverage applications. They feature in line cleaning, a pressure gauge, and a small footprint for bench use (or under hood).

Standard features included with all HC Series Homogenizers:

• In-line cleaning high pressure tubing
• Pressure gauge (non-sanitary type)
• Small footprint for bench use, or under hood

Microfluidics LM10 Microfluidizer® High Pressure Lab Homogenizer is a unique solution to maintaining consistent process pressure, ensures 100% of your material gets exactly the same treatment.

The new LM10 Microfluidizer is a digitally controlled lab unit for small sample material processing. The LM10 converts pressure energy more efficiently into shear and impact forces, attaining targeted size reduction at lower peak pressure, which results in less sample temperature rise during processing.

The micro-channel architecture of each interaction chamber enables linear volumetric scale-up for larger capacity processing, guaranteeing process performance at pilot/production scales, and minimizing additional development time.

M-110EH-30 Electric-Hydraulic Laboratory Microfluidizer Processor for Continuous High Shear Fluid Processing. The M-110EH-30 has been designed to reliably achieve continuous operating pressures to 30,000 psi. The processor maximizes the energy-per-unit fluid volume, resulting in uniform submicron particle and droplet sizes. Utilizing Microfluidics’ fixed geometry diamond interaction chamber technology, nd a ceramic (Zirconia) plunger, the M-110EH-30 is capable of processing a wide variety of fluids such as simple oil-in-water emulsions, solids-in-liquid suspensions, and cell disruptions, including the most difficult yeasts and plant cells, in 1-2 passes. What’s more, the process is repeatable and is guaranteed to scaleup to pilot and/or production volumes.

M-110P Laboratory Model For Continuous High Shear Fluid Processing The M-110P Microfluidizer is the industry’s leading high shear fluid processor with simplified usage controls, cooler operation, and reduced weight and noise.

The new M-110P lab homogenizer works anywhere, without compressed air or hydraulic cooling water. Running on a standard 120-volt, 20-amp, single-phase power outlet, the M-110P delivers:

• Production of stable nanodispersions and nanoemulsions
• Cell Disruption (e. coli, yeast, etc.)
• Micro/nanoencapsulation in polymers, liposomes and oils
• Deagglomeration

The M-110P lab homogenizer has been designed to reliably achieve continuous operating pressures up to 30,000 psi (2069 bar). This processor maximizes the energy-per-unit fluid volume, resulting in uniform submicron particles.

High Pressure Laboratory Microfluidizer Processor for High-Shear Fluid Processing

M-110Y Microfluidizer processor is a lab machine that provides the highest shear rates of any competitive processing equipment on the market today, maximizing the energy-perunit fluid volume to produce uniform submicron particle and droplet sizes. Process pressures range from 206-1586 bar (3,000-23,000 psi), enabling the processing of a wide variety of products ranging from simple oilin-water emulsions to high-weightpercent solids in liquid suspensions, as well as low to high concentration cell disruption. The system is easy to operate and is designed for clean-inplace without disassembly.

Recommended for:

• Cell disruption
• Nanoemulsions
• Nanodispersions
• Submicron liposomes
• Submicron encapsulation
• Microcapsules

Microfluidizer Processor for Continuous High Shear Fluid Processing in Industrial Environments. Microfluidics produces patented Microfluidizer processor equipment with high-pressure, fixed-geometry interaction chambers that impart high shear rates to product formulations. The M-700 generates up to 30,000 psi operating pressure (40,000 psi available as special option) for premium results at an affordable cost.

The MP350 Microlyser™ Processor is an innovation in high shear processing which utilizes a hybrid approach by incorporating Microfluidics proprietary Interaction Chamber™ technology with a unique electric pumping system, to deliver the highest cell disruption yields.

From E. coli to difficult yeast cells, the MP350 Microlyser™ can provide consistent pressure across the batch cycle to maximize protein yields and ensure high product quality in cell disruption of various cells. It has the same multi-slotted fixed-geometry Interaction Chamber™ that all Microfluidics equipment possess which provides consistent shear & uniform processing for reduced batch time & lesser passes.

The scale up to production volumes with the MP350 model is seamless & cost effective once the suitable cell disruption lab and pilot batches are achieved. Enquire with us today!